Discovery Of Anti-Hcv And Ns5b Rdrp Inhibition Activities Of Novel Anthraquinones By In Vitroand In Silico Approach

Original Article

Abstract

A confirmed target for drug development, the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase
(RdRP) is a crucial and unique part of the HCV RNA replication machinery. We describe the identification of
compounds with anti-HCV and NS5B RdRp inhibitory activity in this research investigation. Here, we investigated
the activity of anthraquinone compounds using both an in vitro and an in silico method. These substances were discovered to be active with strong anti-HCV and NS5B RdRp inhibitory properties. Our findings also suggest that
anthraquinones may be optimized and that novel anthraquinone derivatives with enhanced cell and enzyme-based
activity may produced.
Keywords: RNA-dependent RNA polymerase, anthraquinones, molecular docking, hepatitis C virus, and NS5B
inhibitors