Knowledge And Practices Of Pediatricians About Chelation Therapy In Transfusion-Dependent Thalassemia Major

Original Article

Abstract

Objective: To evaluate the knowledge regarding chelation therapy among pediatricians treating transfusion- dependent thalassemia major children and to improve treatment strategies in order to better manage this disorder.

Study Design: A Cross-Sectional Study

Place and Duration of Study: The study was conducted at the Department of Pediatrics, Bolan Medical College/Hospital, located in Quetta, Pakistan. The data collection took place over a period of six months From December 2023 To May 2024.

Methods: 94 participants at Department of Pediatrics Bolan Medical Complex Hospital Quetta. Baluchistan. The data was collected by a structured questionnaire which included three major sections including sociodemographic characteristics, knowledge and practices. Scores were ranged poor (0–4), fair (5–8), and satisfactory (9–12). Data were analyzed with SPSS version 24. Normality was tested by Shapiro–Wilk test and we used chi-square or Fisher’s exact test to examine associations with significance set at p<0.05p < 0.05p<0.05.

Results: The means±s.d.m of knowledge score was 7.8±2.2 and satisfactory knowledge was found in 16.3%. Years of experience and the association with the knowledge scores had significant associations p=0.03p=0.03p=0.03. Practices differed considerably, with 82.7% of practices preferring combination therapy.

Conclusions: There is high variability in pediatricians’ knowledge and practice about chelation therapy in TDT. Though some showed sufficient understanding, many lacked important knowledge. There is a need for more rigorous adherence to guidelines and training sessions to improve the competency of pediatricians in the management of TDT. This will promote compliance, decrease side effects, and provide better outcomes.