Evaluation Of Ciprofloxacin And Ceftriaxone’s Efficacy In The Treatment Of Gonorrhoea

Original Article

Abstract

Background: A very infectious bacterial illness that may infect both men and women via sexual contact is
gonorrhea, a serious public health hazard. It is among the most ancient sexually transmitted infections (STDs), and
Neisseria is the cause. Rarely, gonorrhea may also result in pharyngeal, ocular, articular, and dermatological conditions
in addition to its predominant urogenital signs and symptoms. Gonorrhea has been treated with various antibiotics,
including spectinomycin, cephalosporins, tetracyclines, macrolides, sulpha medicines, and fluoroquinolones. Some of
these medications are no longer used to treat gonorrhea due to an increase in resistant infections.
OBJECTIVE: This research compared the efficaciousness of Ceftriaxone and ciprofloxacin in managing gonococcal
infections.
STUDY DESIGN: A- Observational- Study
Place And Duration of Study: The study was conducted in New Gulail Polyclinic, Saudi Arabia, from January
2003 to March 2004.
METHODS: With the institutional Ethical Committee’s consent, 200 patients received Ceftriaxone and ciprofloxacin to treat gonorrhea. Enrolling the patients included the use of a purposeful sampling approach. Every patient
was divided into two groups of 100 individuals, each at random. Group B received a single intravenous dose of 500
mg of Ceftriaxone Injection, whereas Group A received a 500 mg tablet of Ciprofloxacin. After five days, all of the
patients had follow-up examinations, and their lab and clinical test results were documented and evaluated.
RESULTS: Patients in Group A (n=100) receiving ciprofloxacin demonstrated 80% full response, 9% partial
response, and 11% showed no improvement on the fifth day after therapy. On the other hand, patients taking ceftriaxone
in Group B (n=100) had 90% complete responses, 4% partial responses, and 6% no responses at all.
To sum up, Ceftriaxone treated gonorrhea more well than ciprofloxacin. It is recommended that all patients get a
follow-up examination to confirm the whole course of therapy for gonorrhea after taking a single antibiotic dosage.
KEYWORDS: Neisseria gonorrhea, sexually transmitted infection (STI), Sexually Transmitted Disease (STD)