Effect Of Fluor Quinolones On Qt Interval

Original Article

Abstract

Objective: To assess how recently introduced quinolones affect the electrocardiogram’s Qtc interval
Study Design: A Cross-sectional analytical study
Duration And Place Of Study: MMC Mardan from December 2015 to September 2016
Materials and Methods: In MMC Mardan, cross-sectional analytical research was conducted between December
2015 and September 2016. The research comprised 110 participants, regardless of age or gender, who were hospitalized in the medical department for whatever reason and weren’t already on fluoroquinolones. Informed consent
was obtained before quinolones were administered. Three duplicate baseline ECGs were collected before the injection
of quinolones, and three triplicate ECGs were taken 48 hours later. To prevent bias, each participant’s ECG was
scrambled and read by a single person.
Result: A total of 110 patients underwent evaluation for the research. Thirteen females and nineteen males, making
up the 32 patients, had QTc interval prolongation up to 450 ms and 470 ms, respectively. There is a danger to TdP
when QTc prolongation of more than 500 ms or a post-dose QTc alteration of more than 60 ms is present in 27
patients, 13 of whom were female and 14 of whom were male.
Conclusion: The ability to extend the Qtc interval is shared by all quinolones. Of the quinolones utilized in the
research, moxifloxacin tended to extend the QTc interval.
Key Words: Fluoroquinolones, QT interval calculated (QTc), Torsades de Pointes (TdP).