Typhoid-Related Positive Pattern Of Antibiotic Sensitivity In Blood Cultures A Cross-Sectional Study

Original Article

Abstract

Objective: The study aims to determine the pattern of antibiotic sensitivity in typhoid patients with positive blood
cultures.
Study Design: A cross-sectional study.
Place and Duration of the Study: Department of Medicine, MTI, LRH Peshawar, Pakistan from Jan 05
2019 to Dec 05 2019.
Methods: One hundred male and female patients attended. Patients ranged from 10 to 55. Each patient’s age, gender, and BMI were collected after informed written permission. Each patient had a fever. Each patient was tested for
salmonella in their blood. The Kirby Bauer Disc Diffusion technique was used by NCCLS to measure and interpret
antibiotic susceptibility. Research data was evaluated using SPSS 22.0.
Results: The 100 patients were 42 (42.6%) female and 58 (58.4%) male. Most of the 40 patients (40.2%) were
15–25. Paratyphi 30 (30.6%) was less common than typhi 65 (65.4%). Our investigation found that azithromycin,
cotrimoxazole, gentamicin, chloramphenicol, and azithromycin were more sensitive than ciprofloxacin and ofloxacin
(10.2% vs. 7.1%). Both medicines have significant resistance. Salmonella typhi was resistant to 94 (94.4%) nalidixic
acids.
Conclusion: We found a wide range of antimicrobial sensitivity patterns, including significant cotrimoxazole and
chloramphenicol sensitivity. For 18 years, quinolones have been routinely utilized yet have low sensitivity.
Keywords: Typhoid, Antibiotic sensitivity, Blood cultures, Salmonella, Quinolones