Effect Of Fluor Quinolones On Qt Interval

• ORIGINAL ARTICLE | ISSUE DETAILS: VOL NO.2 | ISSUE NO. 1

Abstract

Objective: To assess how recently introduced quinolones affect the electrocardiogram’s Qtc interval

Study Design: A Cross-sectional analytical study

Duration And Place Of Study: MMC Mardan from December 2015 to September 2016

Materials and Methods: In MMC Mardan, cross-sectional analytical research was conducted between December 2015 and September 2016. The research comprised 110 participants, regardless of age or gender, who were hospitalized in the medical department for whatever reason and weren’t already on fluoroquinolones. Informed consent was obtained before quinolones were administered. Three duplicate baseline ECGs were collected before the injection of quinolones, and three triplicate ECGs were taken 48 hours later. To prevent bias, each participant’s ECG was scrambled and read by a single person.

Result: A total of 110 patients underwent evaluation for the research. Thirteen females and nineteen males, making up the 32 patients, had QTc interval prolongation up to 450 ms and 470 ms, respectively. There is a danger to TdP when QTc prolongation of more than 500 ms or a post-dose QTc alteration of more than 60 ms is present in 27 patients, 13 of whom were female and 14 of whom were male.

Conclusion: The ability to extend the Qtc interval is shared by all quinolones. Of the quinolones utilized in the research, moxifloxacin tended to extend the QTc interval.